mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism.
Autism spectrum disorders (ASD) are highly disabling developmental disorders with a population prevalence of 1-3%.Despite a strong genetic etiology, there are no current baseball scoreboards for sale therapeutic options that target the core symptoms of ASD.Emerging evidence suggests that dysfunction of glutamatergic signaling, in particular through